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Association Study of Matrix Metalloproteinases Gene Polymorphisms with Susceptibility to Rheumatoid Arthritis: A

Peng Li1,2, Sha-Sha Tao1,2, Meng-Qin Zhao1,2

  • 1a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , PR China and.

Immunological Investigations
|October 6, 2015
PubMed
Abstract

Insights

This meta-analysis found no significant link between matrix metalloproteinases (MMPs) gene variants like MMP-1, MMP-3, and MMP-9 and rheumatoid arthritis (RA) susceptibility. However, a weak association was noted for MMP-2 gene polymorphisms and RA risk.

Area of Science:

  • Genetics and Immunology
  • Molecular Biology
  • Rheumatology

Background:

  • The association between matrix metalloproteinases (MMPs) gene polymorphisms and rheumatoid arthritis (RA) susceptibility remains controversial.
  • MMPs play crucial roles in extracellular matrix degradation, influencing joint inflammation and destruction in RA.

Purpose of the Study:

  • To clarify the association between specific matrix metalloproteinases (MMP-1, MMP-2, MMP-3, MMP-9) gene polymorphisms and rheumatoid arthritis (RA) susceptibility.
  • To conduct a comprehensive meta-analysis of existing studies to resolve conflicting findings.

Main Methods:

  • Systematic literature search of PUBMED, EMBASE, and CNKI databases up to January 2015.
  • Inclusion of studies investigating MMP-1, MMP-2, MMP-3, and MMP-9 gene polymorphisms in relation to RA.
  • Application of fixed-effects or random-effects models based on heterogeneity to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs).

Main Results:

  • Eleven studies with 2143 cases and 2049 controls were included.
  • No significant associations were found for MMP-1-1607 1G/2G, MMP-3-1171 5A/6A, and MMP-9-1562 C/T polymorphisms with RA susceptibility in overall or Caucasian populations.
  • A weak association was observed between MMP-2-1306 C/T polymorphism and RA susceptibility (OR = 0.813, 95% CI = 0.694-0.953).

Conclusions:

  • MMP-1, MMP-3, and MMP-9 gene polymorphisms are not significantly associated with rheumatoid arthritis susceptibility.
  • MMP-2 -1306 C/T polymorphism shows a weak association with rheumatoid arthritis susceptibility.
  • Further large-scale studies are warranted to confirm these findings and establish definitive conclusions.
Keywords:
Matrix metalloproteinasemeta-analysispolymorphismrheumatoid arthritissusceptibility

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