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Statins and their increased risk of inducing diabetes

Aris P Agouridis1,2, Michael S Kostapanos3, Moses S Elisaf2

  • 1a 1 Department of Clinical Biochemistry (Vascular Disease Prevention Clinics), Royal Free London Foundation Trust , Pond Street, London, UK.

Expert Opinion on Drug Safety
|October 6, 2015
PubMed
Abstract

Insights

Statins prevent cardiovascular disease but may increase new-onset diabetes risk, especially high-intensity statins in at-risk patients. Cardiovascular benefits generally outweigh diabetes risks, but caution is advised.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Pharmacology

Background:

  • Statins are proven cardiovascular disease preventatives.
  • A potential increased risk of new-onset diabetes (NOD) with statin use has been debated.

Purpose of the Study:

  • To review recent evidence on statin use and diabetes risk.
  • To explore mechanisms underlying statin-induced glucose homeostasis alterations.

Main Methods:

  • Literature search of PubMed for articles published January 2010-May 2015.
  • Included search terms: statins, diabetes, glucose, insulin.
  • Focused on original articles and reviews.

Main Results:

  • Higher intensity statin therapy is associated with greater NOD risk.
  • Patients with pre-existing diabetes risk factors experience a more pronounced increase in NOD risk.
  • Statins may impair pancreatic beta-cell insulin secretion and increase tissue insulin resistance.

Conclusions:

  • The cardiovascular benefits of statins outweigh the associated diabetes risk.
  • Caution is recommended when prescribing statins to patients at high risk for developing diabetes.
Keywords:
cardiovascular diseasenew onset diabetesstatin

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