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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Atherosclerosis III: Management01:26

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Coronary Artery Disease II: Pathophysiology01:26

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Coronary Artery Disease I: Introduction01:30

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Atherosclerosis IV: Nursing Management01:23

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Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
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Computational modelling of atherosclerosis.

Andrew Parton, Victoria McGilligan, Maurice O'Kane

    Briefings in Bioinformatics
    |October 7, 2015
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    Summary
    This summary is machine-generated.

    Mathematical and computational modeling offers a framework to understand atherosclerosis dynamics. This approach integrates multiple factors to explore disease mechanisms and develop new therapeutic hypotheses for cardiovascular disease.

    Keywords:
    atherosclerosiscardiovascular diseasecholesterolcomputational biologymodelingsystems biology

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    Area of Science:

    • Cardiovascular Disease Research
    • Computational Biology
    • Mathematical Modeling

    Background:

    • Atherosclerosis is a major cardiovascular disease pathology linked to elevated cholesterol.
    • An estimated 2.5 million deaths annually are attributed to high cholesterol, posing a global health risk.
    • The complex interplay of hemodynamics, endothelial damage, immunity, and sterol biochemistry drives atherosclerosis, yet remains poorly understood.

    Purpose of the Study:

    • To review the current state of mathematical and computational modeling in atherosclerosis research.
    • To consolidate recent findings and highlight the scope of existing work.
    • To identify knowledge gaps and future research opportunities in modeling atherosclerosis.

    Main Methods:

    • Utilizing mathematical and computational modeling as a framework to study complex, multi-scale disease dynamics.
    • Integrating various etiological factors within a unified computational model.
    • Reviewing and synthesizing existing literature on atherosclerosis modeling.

    Main Results:

    • A growing interest in applying computational models to understand atherosclerosis is evident.
    • Existing models provide an integrated description of the disease, serving as in silico experimental systems.
    • The current body of work, though limited, shows promise for developing therapeutic hypotheses.

    Conclusions:

    • Mathematical and computational modeling is a crucial framework for understanding the dynamics of atherosclerosis.
    • Further research is needed to address the gaps identified in current modeling approaches.
    • This nascent field holds significant potential for advancing our understanding and treatment of cardiovascular disease.