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Updated: Apr 1, 2026

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes

Published on: June 10, 2021

In Vitro Models for Neurogenesis.

Hassan Azari¹, Brent A Reynolds²

¹Department of Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, Florida 32611 Neural Stem Cell and Regenerative Neuroscience Laboratory, Department of Anatomical Sciences & Shiraz Stem Cell Institute, Shiraz University of Medical Sciences, Shiraz, Iran.

Cold Spring Harbor Perspectives in Biology

|October 7, 2015

Summary

This summary is machine-generated.

This study reviews in vitro models for neurogenesis, the process of creating new neurons. These models help overcome challenges in studying brain development and may aid regenerative neuroscience therapies.

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Last Updated: Apr 1, 2026

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes

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Published on: June 10, 2021

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Published on: September 29, 2023

Area of Science:

Neuroscience
Developmental Biology
Cell Biology

Background:

Neurogenesis, the generation of new neurons, occurs throughout life in specific brain regions.
Understanding neurogenesis is crucial for developing regenerative neuroscience therapies.
In vivo studies face challenges due to nervous system complexity and confounding variables.

Purpose of the Study:

To provide an overview of current in vitro cell-based models of neurogenesis.
To highlight the utility of in vitro models in overcoming in vivo study limitations.
To discuss the recapitulation of in vivo neurogenic processes in vitro.

Main Methods:

Literature review of existing in vitro cell-based models of neurogenesis.
Analysis of model systems that recapitulate key aspects of in vivo neurogenesis.
Discussion of the advantages and limitations of various in vitro approaches.

Main Results:

Several in vitro models exist that mimic aspects of mammalian neurogenesis.
These models offer simplified, robust systems for studying neuronal development.
In vitro models facilitate the investigation of neuronal cell biology and interactions.

Conclusions:

In vitro models are valuable tools for studying complex neurogenesis processes.
These models can advance our understanding of neuronal development and function.
In vitro approaches are essential for developing future therapeutic strategies in regenerative neuroscience.