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Published on: August 8, 2022
CARD9 mutation linked to Corynespora cassiicola infection in a Chinese patient
X X Yan1,2,3, C P Yu2,3, X A Fu3,4
1Shandong Clinical College of Skin Diseases, Anhui Medical University, Jinan, Shandong, China.
Abstract:
Corynespora cassiicola is a plant pathogen associated with leaf-spotting disease. The fungus has been found on diverse substrates: leaves, stems and roots of plants; nematode cysts and human skin. It rarely causes human infections. Here we report one case of subcutaneous phaeohyphomycosis caused by C. cassiicola with prominent tissue necrosis in a woman. All of her clinical features pointed towards a genetic linkage. Hence, whole-exome sequencing and Sanger sequencing were performed on this patient. One mutation of CARD9 was detected.
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