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Cryptococcus neoformans and Streptococcus pneumoniae co-infection in post-traumatic meningitis in a patient with

Faryal Saleem1, Naima Fasih1, Afia Zafar1

  • 1Department of Pathology and Microbiology, Aga Khan University Hospital, Karachi, Pakistan.

JPMA. the Journal of the Pakistan Medical Association
|October 7, 2015
PubMed

Insights

Mixed bacterial and fungal meningitis is rare. This case highlights a co-infection with Cryptococcus neoformans and Streptococcus pneumoniae, emphasizing the need for thorough cerebrospinal fluid screening and immunodeficiency assessment.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Neurology

Background:

  • Meningitis presents significant morbidity and mortality.
  • Mixed bacterial and fungal meningeal infections are exceptionally rare.

Observation:

  • A case of co-infection with Cryptococcus neoformans and Streptococcus pneumoniae is reported.
  • The patient had an unknown human immunodeficiency virus status.

Findings:

  • This case underscores the rarity of mixed bacterial-fungal meningitis.
  • Cerebrospinal fluid screening must exclude multiple pathogens.

Implications:

  • Patients with opportunistic organisms like Cryptococcus require immunodeficiency assessment.
  • Thorough diagnostic workups are crucial for rare co-infections.
Keywords:
Cryptococcosis, Meningeal co-infections, Cryptococcal meningitis, Post-traumatic meningitis.

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