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Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
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Autoimmune pancreatitis with extraocular muscles involvement
Abbas Ali Yousuf Tasneem1, Hamza Aasim Yousuf1, Nasir Hassan Luck1
1Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.
JPMA. the Journal of the Pakistan Medical Association
|October 7, 2015
Summary
Autoimmune pancreatitis, a condition causing pancreatic inflammation, can manifest with eye and bile duct issues. This case highlights successful treatment with corticosteroids, resolving symptoms like exophthalmos and jaundice.
Area of Science:
- Gastroenterology
- Immunology
- Ophthalmology
Background:
- Autoimmune pancreatitis (AIP) is a chronic inflammatory condition of the pancreas.
- It is characterized by pancreatic enlargement, ductal narrowing, lymphoplasmacytic infiltration, and fibrosis.
- AIP is known to be responsive to corticosteroid therapy.
Observation:
- A 32-year-old male presented with unilateral exophthalmos and obstructive jaundice.
- Imaging revealed a pancreatic head mass and biliary tract stricture.
- Elevated serum immunoglobulin G (IgG) levels, particularly IgG4 subclass, were noted.
Findings:
- Ophthalmological examination showed unilateral thickening of extraocular muscles.
- The patient received corticosteroid treatment.
- Significant improvement was observed with resolution of biliary strictures, pancreatic head mass, and exophthalmos.
Implications:
- This case underscores the diverse clinical presentations of autoimmune pancreatitis, including extraglandular manifestations like exophthalmos.
- It reinforces the efficacy of corticosteroid therapy in managing both pancreatic and associated extraglandular symptoms of IgG4-related disease.
- Early recognition and treatment are crucial for favorable outcomes in patients with autoimmune pancreatitis and IgG4 elevation.
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