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Introduction to Fillers.

Jean Carruthers1, Alastair Carruthers, Shannon Humphrey

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Injectable soft-tissue fillers are widely used in cosmetic therapy. Biodegradable fillers offer sustained aesthetic improvements with fewer risks compared to permanent implants.

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Area of Science:

  • Dermatology
  • Cosmetic Surgery

Background:

  • Injectable soft-tissue fillers are integral to modern cosmetic therapy.
  • Products are designed for facial lines, folds, and revolumization.

Purpose of the Study:

  • Review FDA-approved cosmetic fillers.
  • Discuss new cosmetic filler agents under investigation in the U.S.

Main Methods:

  • Literature review of cosmetic filler products.
  • Analysis of product characteristics and clinical outcomes.

Main Results:

  • Practitioners prefer biodegradable agents stimulating neocollagenesis for sustained results (up to a year+) with minimal side effects.
  • Permanent implants offer longevity but carry higher complication risks, requiring experienced injectors.

Conclusions:

  • Both biodegradable and nonbiodegradable fillers are available or under investigation.
  • Product selection depends on injector preference and treatment area.
  • Modern biodegradable fillers are durable, reversible, and offer significant benefits.