Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lysogenic Cycle of Bacteriophages00:43

Lysogenic Cycle of Bacteriophages

69.6K
In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
69.6K
Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

80.1K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
80.1K
DNA Bacteriophages01:26

DNA Bacteriophages

1.4K
Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
1.4K
Viral Replication: Lytic Cycle01:20

Viral Replication: Lytic Cycle

2.6K
Bacteriophages, or phages, are viruses that specifically infect bacteria. Among them, T-even bacteriophages, such as T4, exhibit a well-characterized lytic replication cycle in Escherichia coli (E. coli). This process ensures the rapid proliferation of the virus while ultimately leading to the destruction of the bacterial host.Attachment and DNA InjectionThe infection process begins with the recognition and binding of the T4 phage to the E. coli cell surface. Tail fibers of the phage...
2.6K
Viral Replication: Lysogenic Cycle01:16

Viral Replication: Lysogenic Cycle

2.4K
The lysogenic cycle is a crucial viral replication strategy that allows bacteriophages to persist within host cells without immediately destroying them. This process is primarily observed in temperate phages, such as bacteriophage lambda (λ), which infects Escherichia coli. The cycle allows the viral genome to persist across bacterial generations while keeping host cells viable.Integration of the Viral GenomeUpon infection, bacteriophage lambda attaches to the bacterial surface and injects...
2.4K
Phagocytosis00:41

Phagocytosis

96.4K
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.
96.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of a novel virulent mycobacteriophage Kashi-SSH1 (KSSH1) depicting genus-specific broad-spectrum anti-mycobacterial activity.

Life sciences·2025
Same author

Models of Classroom Assessment for Course-Based Research Experiences.

Frontiers in education·2024
Same author

Isolation and characterization of a novel mycobacteriophage Kashi-VT1 infecting <i>Mycobacterium</i> species.

Frontiers in cellular and infection microbiology·2023
Same author

Evidence of a Set of Core-Function Genes in 16 Bacillus Podoviral Genomes with Considerable Genomic Diversity.

Viruses·2023
Same author

Crowdsourcing biocuration: The Community Assessment of Community Annotation with Ontologies (CACAO).

PLoS computational biology·2021
Same author

Complete Genome Sequence of Bacillus amyloliquefaciens Bacteriophage Ray17.

Microbiology resource announcements·2019

Related Experiment Video

Updated: Apr 1, 2026

Following Cell-fate in E. coli After Infection by Phage Lambda
06:10

Following Cell-fate in E. coli After Infection by Phage Lambda

Published on: October 14, 2011

24.4K

Phage on the stage.

Louise Temple1, Lynn Lewis1

  • 1Department of Integrated Science & Technology; James Madison University ; Harrisonburg, VA USA ; Department of Biological Sciences; University of Mary Washington ; Fredericksburg, VA USA.

Bacteriophage
|October 7, 2015
PubMed
Summary

This educational program uses bacteriophages to teach undergraduate students about antibiotic-resistant bacteria. It fosters hands-on learning, leading to new phage discoveries and preparing future scientists.

Keywords:
Bacteriophagesbioinformaticsgenomicsoriginal researchphage discoveryphage methodsundergraduate education

More Related Videos

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

13.0K
Author Spotlight: Advancing Protein Engineering &#8211; Harnessing Evolution Through PRANCE and Lab Automation
05:08

Author Spotlight: Advancing Protein Engineering – Harnessing Evolution Through PRANCE and Lab Automation

Published on: January 12, 2024

2.4K

Related Experiment Videos

Last Updated: Apr 1, 2026

Following Cell-fate in E. coli After Infection by Phage Lambda
06:10

Following Cell-fate in E. coli After Infection by Phage Lambda

Published on: October 14, 2011

24.4K
Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

13.0K
Author Spotlight: Advancing Protein Engineering &#8211; Harnessing Evolution Through PRANCE and Lab Automation
05:08

Author Spotlight: Advancing Protein Engineering – Harnessing Evolution Through PRANCE and Lab Automation

Published on: January 12, 2024

2.4K

Area of Science:

  • Microbiology and Virology
  • Science Education
  • Bioinformatics

Background:

  • Growing antibiotic resistance necessitates novel therapeutic strategies, increasing interest in bacteriophages.
  • There is a critical need for enhanced science education, particularly hands-on learning for undergraduates.
  • Bacteriophages (phages) are viruses that infect bacteria and show promise in combating bacterial infections.

Purpose of the Study:

  • To describe an innovative undergraduate educational model centered on bacteriophage discovery.
  • To highlight the integration of hands-on laboratory work with bioinformatics analysis.
  • To assess the program's impact on student engagement and scientific preparedness.

Main Methods:

  • Students engage in discovering unique bacteriophages, isolating and purifying phage DNA.
  • Sequencing of a subset of phage genomes.
  • Bioinformatic analysis of phage genomes to understand their characteristics and potential applications.

Main Results:

  • The program involves over 85 colleges and universities, with students actively participating in phage research.
  • Regular publications are emerging from this initiative, detailing phage discoveries and genomic studies.
  • The model is adaptable and being adopted by various institutions with different bacterial hosts.

Conclusions:

  • This bacteriophage discovery model is a highly accessible and effective approach for undergraduate science education.
  • The program successfully captures student interest during a critical early academic stage.
  • It is expected to yield a greater number of well-prepared students for careers in science and biotechnology, alongside the discovery of novel phages.