Related Experiment Video

Updated: Apr 1, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.9K

[Diagnostic Significance of BAT in Anaphylaxis to Non-ionic Contrast Media]

Hao-yue Zhang, Su-jun Xu, Xiao-xian Tang

    Fa Yi Xue Za Zhi
    |October 8, 2015
    PubMed
    Abstract

    More Related Videos

    Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity10:22

    Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

    Published on: September 16, 2011

    34.3K
    Humanized Mediator Release Assay as a Read-Out for Allergen Potency10:22

    Humanized Mediator Release Assay as a Read-Out for Allergen Potency

    Published on: June 29, 2021

    4.1K

    Related Concept Videos

    Allergic Reactions: Anaphylaxis01:30

    Allergic Reactions: Anaphylaxis

    Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
    177
    Allergic Reactions02:06

    Allergic Reactions

    Overview
    33.6K
    Allergic Drug Reactions01:27

    Allergic Drug Reactions

    Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
    1.6K
    Drug Toxicity: Allergic Reactions01:30

    Drug Toxicity: Allergic Reactions

    Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
    140
    Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

    Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

    Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
    Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
    2.3K
    Hypersensitivity Reactions: Immune-Complex Reactions01:19

    Hypersensitivity Reactions: Immune-Complex Reactions

    Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
    163