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[Side Effects of Continuous Fentanyl Infusion for Postoperative Pain Relief in Children]

Shizuko Kabara, Tetsuro Kagawa, Noriyuki Ikejima

    Masui. the Japanese Journal of Anesthesiology
    |October 8, 2015
    PubMed

    Insights

    Continuous fentanyl infusion can safely manage pediatric postoperative pain. Close monitoring for respiratory depression and managing nausea/vomiting are essential for safe and effective pain relief in children.

    Area of Science:

    • Pediatric Anesthesiology
    • Pain Management
    • Pharmacology

    Background:

    • Limited data exists on fentanyl use for pediatric postoperative pain relief compared to morphine.
    • This study focuses on detailing side effects in children receiving continuous fentanyl infusion.

    Purpose of the Study:

    • To clarify the side effects of continuous fentanyl infusion for postoperative pain relief in children.
    • To assess the safety and efficacy of fentanyl in pediatric pain management.

    Main Methods:

    • Retrospective examination of 1,166 children (0-14 years) receiving continuous fentanyl infusion (0.5 or 1.0 μg/kg/hr) over 4 years.
    • Continuous pulse oximetry monitoring with regular recording of vital signs, SpO2, respiratory rate, blood pressure, and sedation scores.
    • Documentation of nausea/vomiting incidence.

    Main Results:

    • Severe side effects, including respiratory depression requiring intervention, occurred in 0.77% of cases.
    • No fatalities or permanent sequelae were reported.
    • Nausea/vomiting was observed in 25.4% of the pediatric patients.

    Conclusions:

    • Continuous fentanyl infusion is safe for pediatric postoperative pain relief when supported by monitoring systems for early detection of respiratory depression.
    • Proactive measures against nausea and vomiting are necessary for optimal patient care.
    Abstract

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