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A proteomic glimpse into human ureter proteome.

Sameh Magdeldin1,2,3, Yoshitoshi Hirao1, Amr Elguoshy1,4

  • 1Biofluid Biomarker Center (BB-C), Institute for Research Collaboration and Promotion, Niigata University, Niigata, Japan.

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|October 8, 2015
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Summary

This study presents the first comprehensive ureter proteome dataset, identifying 751 proteins found in urine. It also discovered 21 potential ureter-specific proteins, offering new avenues for urology biomarker discovery.

Keywords:
BiomarkerCell biologyDatasetOFFGel fractionationUreterUrine

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Area of Science:

  • Urology
  • Proteomics
  • Biomarker Discovery

Background:

  • Urine is a key biofluid for clinical proteomics due to easy sampling and stability.
  • Urinary protein profiles aid in diagnosing various disorders.
  • The precise origin of urinary proteins within the urogenital (UG) tract is often unclear.

Purpose of the Study:

  • To create the first unbiased ureter proteome dataset.
  • To compare ureter proteome data with urine, urinary exosomes, and kidney proteomes.
  • To identify potential ureter-specific proteins for biomarker development.

Main Methods:

  • Comprehensive proteomic analysis of ureter tissue.
  • Mass spectrometry-based comparison of ureter, urine, urinary exosome, and kidney datasets.
  • Bioinformatic analysis to identify unique ureter proteins against existing databases.

Main Results:

  • A dataset of 2217 nonredundant ureter proteins was established.
  • 751 ureter proteins (33.8%) were detected in urine (as free proteins or exosomes).
  • 21 proteins were identified as potentially unique to ureter tissue after comparison with bladder and prostate databases.

Conclusions:

  • This study provides a valuable ureter proteomic dataset for urology and biomarker research.
  • The findings suggest potential biomarkers for ureter diseases, including ureter carcinoma.
  • The identified ureter-specific proteins open new diagnostic possibilities.