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Related Concept Videos

Cystic Fibrosis: Management01:24

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Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Related Experiment Video

Updated: Apr 1, 2026

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
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Zinc Supplementation for One Year Among Children with Cystic Fibrosis Does Not Decrease Pulmonary Infection.

Ganesh Sharma1, Rakesh Lodha1, Shivaram Shastri1

  • 1Department of Pediatrics.

Respiratory Care
|October 8, 2015
PubMed
Summary
This summary is machine-generated.

Zinc supplementation did not significantly reduce antibiotic use or improve lung function in children with cystic fibrosis. This 12-month study found no difference in outcomes between zinc and placebo groups.

Keywords:
FEV1cystic fibrosismicronutrientspseudomonas infectionzinc supplementation

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Area of Science:

  • Pediatric Pulmonology
  • Nutritional Science
  • Clinical Trials

Background:

  • Children with cystic fibrosis (CF) may experience micronutrient deficiencies, including zinc, potentially increasing infection susceptibility.
  • Limited data exists on zinc supplementation's efficacy in pediatric CF patients.
  • This study investigated if zinc supplementation could reduce antibiotic reliance in children with CF.

Purpose of the Study:

  • To evaluate the effect of daily zinc supplementation on antibiotic use in children with cystic fibrosis.
  • To assess the impact of zinc supplementation on pulmonary function tests (PFTs) in pediatric CF patients.
  • To determine if zinc supplementation influences Pseudomonas colonization or hospitalization rates.

Main Methods:

  • A double-blind, randomized, placebo-controlled trial involving 40 children (age 5-15) with CF.
  • Participants received either 30 mg of zinc or a placebo daily for 12 months, alongside standard care.
  • Outcomes measured included antibiotic administration days, PFTs (FEV1), serum zinc levels, sputum cultures, and adverse events.

Main Results:

  • No significant difference in the median number of antibiotic days (42 vs. 38) between the zinc and placebo groups over 12 months (P = .79).
  • No significant differences observed in percent-predicted FEV1 or change in FEV1 at 12 months (P = .44).
  • Similar rates of Pseudomonas isolation and comparable adverse events were reported in both groups.

Conclusions:

  • Daily 30 mg zinc supplementation did not significantly reduce antibiotic needs, improve pulmonary function, or alter Pseudomonas colonization in children with cystic fibrosis.
  • The findings suggest that zinc supplementation at this dosage is not effective for improving key clinical outcomes in this population.
  • Further research may be needed to explore different dosages or specific subgroups of CF patients.