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Related Experiment Video

Updated: Apr 1, 2026

Real-Time Quantification of Reactive Oxygen Species in Neutrophils Infected with Meningitic Escherichia Coli

Real-Time Quantification of Reactive Oxygen Species in Neutrophils Infected with Meningitic Escherichia Coli

Published on: April 20, 2021

Meningitis-Associated Escherichia coli.

|October 8, 2015

Summary

Neonatal meningitis caused by Escherichia coli (E. coli) is a significant global health issue. Understanding E. coli

Area of Science:

Microbiology
Infectious Diseases
Pathogenesis

Background:

Neonatal meningitis is frequently caused by Gram-negative bacteria, with Escherichia coli (E. coli) being the most common pathogen.
E. coli meningitis contributes significantly to global mortality and morbidity, with pathogenesis and pathophysiology remaining incompletely understood.
Emerging antibiotic resistance in E. coli strains, such as those producing extended-spectrum β-lactamases, presents a growing clinical challenge.

Purpose of the Study:

To investigate the mechanisms of E. coli penetration into the brain, a critical step in neonatal meningitis.
To identify microbial and host factors involved in E. coli bacteremia and blood-brain barrier invasion.
To explore potential therapeutic targets for preventing and treating E. coli meningitis.

Main Methods:

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Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Published on: December 23, 2022

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Last Updated: Apr 1, 2026

Real-Time Quantification of Reactive Oxygen Species in Neutrophils Infected with Meningitic Escherichia Coli

Real-Time Quantification of Reactive Oxygen Species in Neutrophils Infected with Meningitic Escherichia Coli

Published on: April 20, 2021

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat

Published on: October 29, 2014

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Published on: December 23, 2022

Utilized functional genomic approaches in both in vitro (human brain microvascular endothelial cells) and in vivo (animal models) blood-brain barrier models.
Investigated E. coli factors contributing to high-degree bacteremia.
Examined specific microbial and host factors facilitating E. coli invasion of the blood-brain barrier and host cell signaling molecules.

Main Results:

Identified several E. coli factors that promote high-degree bacteremia.
Discovered specific microbial factors enabling E. coli invasion of the blood-brain barrier.
Demonstrated the involvement of host factors and microbe-host signaling molecules in E. coli brain penetration.
Showed that blocking these factors and signaling molecules effectively prevents E. coli brain entry.

Conclusions:

Continued research into microbial and host factors is crucial for understanding E. coli meningitis.
Identifying these factors will lead to novel therapeutic and preventive strategies against E. coli meningitis.
This research aims to limit the impact of antimicrobial-resistant E. coli infections.