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Related Experiment Video

Updated: Apr 1, 2026

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Guanidinoacetic acid as a performance-enhancing agent.

Sergej M Ostojic1,2

  • 1Biomedical Sciences Department, Faculty of Sport and Physical Education, University of Novi Sad, Lovcenska 16, Novi Sad, 21000, Serbia. sergej.ostojic@chess.edu.rs.

Amino Acids
|October 9, 2015
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Summary

Guanidinoacetic acid (GAA), a creatine precursor, shows promise as a dietary supplement for improving exercise performance. Research indicates potential benefits for physically active individuals, alongside safety and regulatory considerations.

Keywords:
CreatineDietary supplementErgogenicExercise performanceGuanidinoacetic acidSide effects

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Area of Science:

  • Nutritional biochemistry
  • Exercise physiology
  • Sports nutrition

Background:

  • Guanidinoacetic acid (GAA), also known as glycocyamine, is the natural precursor to creatine.
  • First identified in humans approximately 80 years ago, GAA was explored for therapeutic uses in the 1950s.
  • Recent studies suggest potential ergogenic benefits of GAA for physically active populations.

Purpose of the Study:

  • To review the potential applications of Guanidinoacetic acid (GAA) supplementation for enhancing exercise performance.
  • To examine the safety profile of GAA supplementation.
  • To discuss relevant legislation concerning GAA as a dietary agent.

Main Methods:

  • Literature review of existing studies on Guanidinoacetic acid (GAA).
  • Analysis of research on GAA's effects on exercise performance and clinical outcomes.
  • Examination of safety data and regulatory status of GAA.

Main Results:

  • Historical therapeutic use of GAA showed improvements in patient outcomes and work capacity.
  • Emerging research suggests potential ergogenic benefits for physically active men and women.
  • Further investigation into safety and efficacy is ongoing.

Conclusions:

  • Guanidinoacetic acid (GAA) presents a potential avenue for exercise performance enhancement.
  • Comprehensive evaluation of safety and regulatory frameworks is necessary for GAA supplementation.
  • GAA warrants further research as a novel dietary agent for athletes and active individuals.