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Growth of Cartilage and Bone Tissue

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

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Updated: Apr 1, 2026

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

Published on: April 25, 2013

Mechanobioreactors for Cartilage Tissue Engineering.

Joanna F Weber^1,2,3, Roman Perez^4,5, Stephen D Waldman^6,7,8

¹Department of Mechanical & Materials Engineering, Queen's University, Kingston, Canada. weberj@me.queensu.ca.

Methods in Molecular Biology (Clifton, N.J.)

|October 9, 2015

Summary

This summary is machine-generated.

Mechanical stimulation enhances tissue-engineered cartilage. This chapter details methods for applying compression or shear stimuli and analyzing their effects on extracellular matrix synthesis and mechanical properties.

Keywords:

Cartilage Chondrocytes Collagen Mechanical stimulation Mechanotransduction Proteoglycans Tissue engineering

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Last Updated: Apr 1, 2026

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

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Published on: October 27, 2012

Area of Science:

Biomedical Engineering
Tissue Engineering
Biomechanics

Background:

Mechanical stimulation is crucial for developing functional tissue-engineered cartilage.
Optimizing extracellular matrix (ECM) synthesis and mechanical properties is key for cartilage repair.

Purpose of the Study:

To describe methods for applying mechanical stimuli to tissue-engineered cartilage.
To outline analytical techniques for evaluating the impact of mechanical loading.

Main Methods:

Direct mechanical stimulation techniques, including compression and shear loading.
Analytical methods for quantifying ECM synthesis and mechanical property changes post-loading.

Main Results:

Mechanical stimulation effectively increases ECM synthesis.
Improved mechanical properties of engineered cartilage constructs are observed.
Both short-term and long-term loading effects can be quantified.

Conclusions:

Mechanical stimulation is a vital tool in cartilage tissue engineering.
The described methods provide a framework for optimizing engineered cartilage development.
Further research can leverage these techniques for enhanced cartilage regeneration.