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Acyclovir therapy during pregnancy.

Z A Brown1, D A Baker

  • 1Department of Obstetrics and Gynecology, University of Washington, Seattle.

Obstetrics and Gynecology
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

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Acyclovir is not established for pregnancy use. Reasonable uses include severe maternal herpes simplex, varicella pneumonia, and severe genital herpes, but safety and efficacy remain unproven.

Area of Science:

  • Pharmacology
  • Maternal-Fetal Medicine
  • Virology

Background:

  • Acyclovir is an antiviral medication.
  • Pregnancy presents unique challenges for drug use due to potential effects on the fetus.
  • Established indications for acyclovir in pregnant individuals are lacking.

Purpose of the Study:

  • To review potential uses of acyclovir during pregnancy.
  • To discuss the pharmacokinetics of acyclovir in pregnant individuals.
  • To emphasize the lack of established safety and efficacy data for acyclovir in pregnancy.

Main Methods:

  • Literature review of potential acyclovir applications in pregnancy.
  • Analysis of acyclovir pharmacokinetics during pregnancy.
  • Synthesis of current evidence regarding acyclovir use in pregnant populations.

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Main Results:

  • Reasonable indications for acyclovir in pregnancy include disseminated herpes simplex, varicella pneumonia, and severe primary genital herpes.
  • Other potential uses, such as for uncomplicated primary genital herpes or prophylaxis, are considered more problematic.
  • Pharmacokinetic data in pregnancy is limited, and safety, efficacy, and dosage are not established for any indication.

Conclusions:

  • Acyclovir's use in pregnancy is not well-established.
  • Careful consideration is needed for potential benefits versus risks in specific maternal infections.
  • Further research is required to determine the safety, efficacy, and appropriate dosing of acyclovir during pregnancy.