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Published on: April 5, 2015
Intraocular filariasis: a brief review
1Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana 70112.
Abstract:
Fifty-six cases of human intraocular filariasis have been reported. In 6, the objects interpreted as filariae may have been artifacts. In 8, a motile worm that apparently was not a filaria was observed. In the remainder, a motile filaria or filaria-like worm was observed, but in only 6 cases were the filariae removed from the eye, described, and identified. Three of these were identified as Dipetalonema spp., and one each as Wuchereria, Dirofilaria, and Loaina. In 10 cases, filariae were removed and identified as Loa loa (6) or Wuchereria bancrofti (4) but without a supporting description. A filaria was removed but not satisfactorily described or identified in 8 cases, spontaneously disappeared in 4, died following treatment in 4, and met unreported fates in seven. For 3 the original reports were inaccessible. Records of intraocular filariae that are not supported by morphological description are questionable.
Insights
Human intraocular filariasis cases are rare, with few confirmed identifications. Many reported cases lack sufficient evidence, highlighting the need for detailed morphological descriptions for accurate diagnosis of eye worms.
Area of Science:
- Ophthalmology
- Parasitology
- Medical Entomology
Background:
- Intraocular filariasis, caused by parasitic worms in the eye, is a rare condition.
- Accurate identification of the causative filarial species is crucial for diagnosis and treatment.
Purpose of the Study:
- To review and analyze reported cases of human intraocular filariasis.
- To assess the reliability of case reports based on the quality of evidence provided.
Main Methods:
- Systematic review of 56 reported cases of intraocular filariasis.
- Evaluation of case details, including observation of worms, removal, description, and species identification.
Main Results:
- Only a small fraction of reported cases involved confirmed filarial presence with adequate description and identification.
- Identified species included Dipetalonema spp., Wuchereria, Dirofilaria, Loa loa, and Wuchereria bancrofti.
- Many cases were questionable due to lack of morphological description, artifactual findings, or non-filarial organisms.
Conclusions:
- A significant number of intraocular filariasis reports lack sufficient evidence for definitive diagnosis.
- Morphological description and identification are essential for validating cases of intraocular filariasis.
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