Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimising rare tumour risk syndromes care: clinical insights and the PREVENTABLE socioeconomic framework.

European journal of human genetics : EJHG·2026
Same author

Continuation vs Switching Direct Oral Anticoagulant Therapy After Breakthrough Stroke.

JAMA network open·2026
Same author

Differentiating Upper Tract Urothelial Carcinoma with Synchronous or Metachronous Bladder Cancer.

Current issues in molecular biology·2026
Same author

The Long and Winding Road: The Resilience of Cervical Cytology as a Long-Standing Laboratory Tool to Aid the Diagnosis of Human Papillomavirus-Induced Lesions.

Acta cytologica·2026
Same author

Sex Differences in Outcomes After Breakthrough Ischemic Stroke on Oral Anticoagulants for Atrial Fibrillation: An ASPERA-R Inverse Probability Weighted Analysis.

Journal of the American Heart Association·2026
Same author

Frizzled-9 Expression Is Associated With Aggressive Clinicopathological Features and Reduced Overall Survival in Invasive Breast Carcinoma.

Pathology international·2026

Related Experiment Video

Updated: Apr 1, 2026

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer
06:24

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

1.8K

Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival.

Sandra F Martins1, Ricardo Amorim2, Sílvia Coelho Mota3

  • 1Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal ; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Campus of Gualtar, 4710-057 Braga, Portugal ; Surgery Department, Hospitalar Center Trás-os-Montes e Alto Douro, Unidade Hospitalar de Chaves, Avenida Dr. Francisco Sá Carneiro, 5400-279 Chaves, Portugal.

Biomed Research International
|October 9, 2015
PubMed
Summary
This summary is machine-generated.

Ki-67 proliferation marker is decreased in metastatic colorectal cancer (CRC) lymph nodes compared to primary tumors. This suggests lymph node metastasis may be more resistant to cell division-targeting drugs.

More Related Videos

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

12.8K
Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
06:05

Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

Published on: June 2, 2023

10.6K

Related Experiment Videos

Last Updated: Apr 1, 2026

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer
06:24

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

1.8K
Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

12.8K
Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
06:05

Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

Published on: June 2, 2023

10.6K

Area of Science:

  • Oncology
  • Cancer Biology
  • Molecular Pathology

Background:

  • Colorectal cancer (CRC) is a major global health concern, necessitating improved prognostic markers.
  • Current molecular markers for CRC lack the predictive power for disease progression.
  • Targeted therapies require understanding individual tumor biology and specific molecular markers.

Purpose of the Study:

  • To evaluate the Ki-67 proliferation marker in primary colorectal cancer and lymph node metastasis.
  • To determine if Ki-67 expression differs between primary tumors and metastatic sites.
  • To explore the implications of Ki-67 expression for therapeutic resistance.

Main Methods:

  • Immunohistochemical staining for Ki-67.
  • Analysis of Ki-67 positive cell rates in primary CRC tissues.
  • Comparison of Ki-67 expression in primary tumors versus lymph node metastases.

Main Results:

  • A statistically significant difference in Ki-67 positive cell rates was observed between primary and metastatic sites.
  • A notable decrease in Ki-67 positive cells was found in lymph node metastases compared to primary tumors.
  • This suggests reduced proliferation in metastatic CRC cells within lymph nodes.

Conclusions:

  • Ki-67 expression is significantly lower in lymph node metastases of colorectal cancer.
  • Metastatic CRC in lymph nodes may exhibit increased resistance to therapies targeting cellular division.
  • Further research is warranted to confirm therapeutic implications of altered Ki-67 expression in CRC metastasis.