Ratiometically Fluorescent Sensing of Zn(II) Based on Dual-Emission of 2-Pyridylthiazole Derivatives
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Updated: Apr 1, 2026

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
Published on: January 27, 2013
Ming-Hua Zheng1, Xiang Hu1, Ming-Yang Yang1
1Department of Chemistry, Yanbian University, Yanji City, Jilin Province, 133002, China.
Abstract:
A new fluorophore, 4-methyl-2-(2-pyridyl)-5-(2-thiophenyl)thiazole (2-PTT), was reported as a ratiometically fluorescent sensor of zinc(II) based on dual-emission with selectivity and sensitivity. Two emission bands at 440 and 497 nm were observed before and after addition of zinc(II), respectively. Job's plot disclosed the 1:1 stoichiometry between 2-PTT and zinc(II). The binding constant was evaluated as 2.09 × 10(5) M(-1) based on fluorescence titration experiment.
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