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Emerging targets for combination therapy in melanomas

Renata de Freitas Saito1, Tharcísio Citrângulo Tortelli1, Mayara D'Auria Jacomassi1

  • 1Center for Translational Research in Oncology (LIM24), Dept. of Radiology and Oncology, Faculdade de Medicina da Universidade de São Paulo and Instituto do Câncer do Estado de São Paulo, Brazil.

FEBS Letters
|October 10, 2015
PubMed

Insights

Melanoma cells develop resistance to therapies through mechanisms like autophagy and metabolic changes. Targeting these processes offers new avenues for combination therapies against advanced melanoma.

Area of Science:

  • Oncology
  • Cancer Biology

Background:

  • Advanced cutaneous melanomas present significant treatment challenges.
  • Melanoma exhibits high genomic instability and adaptability to harsh conditions.

Purpose of the Study:

  • To review intrinsic and extrinsic resistance mechanisms in melanoma cells.
  • To explore potential therapeutic targets for combination therapies.

Main Methods:

  • Literature review of cellular resistance mechanisms in melanoma.
  • Analysis of biological processes contributing to treatment failure.

Main Results:

  • Identified key resistance mechanisms: autophagy, endoplasmic reticulum stress adaptation, metabolic reprogramming, and tumor repopulation.
  • Highlighted the role of extracellular vesicles in melanoma repopulation.

Conclusions:

  • These resistance mechanisms are potentially targetable.
  • Provides a basis for developing novel combination therapies for melanoma treatment.
Keywords:
AutophagyMelanomaMetabolic reprogrammingPAFTumor repopulationUnfolded protein response

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