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Multiple evanescent white dot syndrome associated with retinal vasculitis
Akihiro Takahashi1, Wataru Saito1, Yuki Hashimoto1
1Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
International Medical Case Reports Journal
|October 10, 2015
Summary
Retinal vasculitis may contribute to inner retinal thickening in multiple evanescent white dot syndrome (MEWDS). This study observed retinal vascular sheathing and leakage in two MEWDS cases, suggesting a potential pathogenic role.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Vascular Diseases
Background:
- Multiple evanescent white dot syndrome (MEWDS) is an idiopathic inflammatory condition affecting the outer retina.
- Previous studies noted inner retinal layer thickening in acute MEWDS, but its cause remains unclear.
Observation:
- Two young myopic women presented with typical MEWDS funduscopic findings, including subretinal white dots and macular granularity.
- Retinal vascular sheathing was observed, with fluorescein angiography showing corresponding leakage.
- Enhanced depth imaging optical coherence tomography revealed ellipsoid zone discontinuity and increased choroidal thickness.
Findings:
- The white dots and retinal vascular sheathing resolved spontaneously within one month.
- Outer retinal morphology and visual acuity recovered within three months.
- The presence of retinal vasculitis was noted in both cases.
Implications:
- These findings suggest that retinal vasculitis may play a role in the pathogenesis of MEWDS.
- Understanding the role of vasculitis could lead to targeted therapeutic strategies for MEWDS.
- Further research is warranted to elucidate the precise mechanisms linking vasculitis and MEWDS.
