Related Experiment Videos
Hydroa Vacciniforme-Like Lymphoproliferative Disorder in the Elderly: A Case Report and Diagnostic Challenges
Xihan Long1, Liyan Lai1, Qiaomin Lin1
1The Seventh Clinical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, People's Republic of China.
Background:
Hydroa vacciniforme-like lymphoproliferative disorder is a rare Epstein-Barr virus -associated T/NK cell proliferation predominantly.
Case Presentation:
A 72-year-old female presented with persistent skin lesions and high fever. The atypical distribution of lesions, along with the spontaneous regression of some of them, and the positive Staphylococcus aureus culture, initially made the diagnostic process complicated. However, skin biopsies revealed CD3+CD8+ T-cell infiltration, partial loss of CD5 expression, a high proliferative index, and positive Epstein-Barr virus-encoded RNA in situ hybridization. Reactive lymph node hyperplasia ruled out systemic lymphoma, thus supporting the diagnosis of HVLPD.
Conclusion:
HVLPD can present in the elderly with lesions in unexposed areas. Diagnostic challenges require accounting for infectious confounders.
Related Concept Videos
Chickenpox
Pneumonia III: Complications and Assessment
Graves' Disease I: Introduction
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Nephrotic Syndrome II : Assessment and Medical Management
Graves Disease II: Pathophysiology