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Therapeutic potential of interleukin-27 against cancers in preclinical mouse models
Izuru Mizoguchi1, Yukino Chiba1, Jun-Ichi Furusawa1
1Department of Immunoregulation; Institute of Medical Science; Tokyo Medical University ; Tokyo, Japan.
Oncoimmunology
|October 10, 2015
Abstract:
Since we first reported the antitumor efficacy of IL-27 in 2004, accumulating evidence obtained by several groups using a variety of preclinical mouse models indicates that IL-27 possesses potent antitumor activity against various types of tumors through multiple mechanisms depending on the characteristics of individual tumors without apparent adverse effects.
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