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Updated: Apr 1, 2026
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
Published on: June 1, 2012
Ex vivo evaluation of a microneedle array device for transdermal application.
Sunaina Indermun1, Yahya E Choonara1, Pradeep Kumar1
1Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa.
This study introduces a novel electro-modulated hydrogel-microneedle array (EMH-MNA) for enhanced transdermal drug delivery. The device significantly increased indomethacin release with electro-stimulation, demonstrating its potential for improved drug administration.
Area of Science:
- Biomedical Engineering
- Materials Science
- Pharmacology
Background:
- Transdermal drug delivery offers advantages over traditional methods.
- Microneedle technology enhances drug permeation across the stratum corneum.
- Advanced drug delivery systems are needed to improve therapeutic efficacy.
Purpose of the Study:
- To introduce a novel transdermal electro-modulated hydrogel-microneedle array (EMH-MNA) device.
- To evaluate the electro-responsive delivery of indomethacin using the EMH-MNA.
- To assess the microbial permeation capabilities of the microneedles.
Main Methods:
- Fabrication of a nano-porous ceramic microneedle array and an optimized electro-modulated hydrogel.
- Ex vivo permeation and drug release studies using porcine skin tissue.
- Comparison of drug release with and without electro-stimulation.
Main Results:
- The EMH-MNA device demonstrated electro-responsive drug delivery capabilities.
- Significantly higher indomethacin release was observed with electro-stimulation (2.93mg) compared to without (0.4540mg).
- Microbial permeation through microneedle-punctured skin was assessed.
Conclusions:
- The novel EMH-MNA device facilitates enhanced transdermal drug delivery.
- Electro-stimulation significantly improves drug release from the microneedle array.
- This technology holds promise for revolutionizing advanced drug delivery systems.
