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Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

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Transparent intracortical microprobe array for simultaneous spatiotemporal optical stimulation and multichannel

Joonhee Lee¹, Ilker Ozden¹, Yoon-Kyu Song^2,3

¹School of Engineering, Brown University, Providence, Rhode Island, USA.

|October 13, 2015

Summary

Researchers developed novel optoelectronic microarrays for simultaneous light delivery and neural sensing. This technology maps brain circuit dynamics and offers potential for advanced optical imaging and stimulation.

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Area of Science:

Neuroscience
Biomedical Engineering
Materials Science

Background:

Optogenetics enables precise control of neural circuits using light, crucial for studying brain function in vivo.
Current limitations exist in devices capable of simultaneous light delivery and neural activity sensing for network-level analysis.
Developing versatile tools is essential for advancing our understanding of complex neural dynamics.

Purpose of the Study:

To create and validate a novel optoelectronic actuator and sensor microarray for simultaneous neural circuit perturbation and recording.
To demonstrate the application of these microarrays in studying light-induced cortical microcircuit dynamics in vivo.
To explore the potential for expanded functionalities including optical imaging and electrical microstimulation.

Main Methods:

Fabrication of monolithic intracortical implants using optically transparent, electrically conductive ZnO semiconductor crystal.
Integration of simultaneous light delivery and electrical readout capabilities within a microprobe array.
Application of the device in transgenic mice to investigate light-perturbed cortical microcircuit dynamics and behavioral effects.

Main Results:

Successful creation of ZnO-based optoelectronic microarrays capable of precise, simultaneous light delivery and electrical recording.
Demonstration of the device's utility in mapping neural population dynamics during optogenetic manipulation in vivo.
Observation of light-perturbed cortical microcircuit dynamics and their impact on behavior in transgenic mouse models.

Conclusions:

The developed optoelectronic microarrays offer a versatile platform for simultaneous optogenetic control and neural sensing.
This technology advances the study of neural circuit dynamics at the network level, particularly in rodent models.
Future applications may include advanced optical imaging and patterned electrical microstimulation for comprehensive neural interfacing.