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A rapid, sensitive colorimetric assay for the high-throughput screening of transaminases in liquid or solid-phase
D Baud1, N Ladkau1, T S Moody2
1Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK. h.c.hailes@ucl.ac.uk.
Chemical Communications (Cambridge, England)
|October 13, 2015
Abstract:
A new colorimetric method has been developed to screen transaminases using an inexpensive amine donor. The assay is sensitive, has a low level of background coloration, and can be used to identify and profile transaminase activities against aldehyde and ketone substrates in a high-throughput format. Significantly it is also amendable to solid phase colony screening.
