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Chemical penetration enhancers.
Luciana B Lopes1,2, Maria Teresa J Garcia3, Maria Vitoria L B Bentley4
1Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, São Paulo, SP, Brazil.
Therapeutic Delivery
|October 13, 2015
Summary
Chemical penetration enhancers are crucial for improving drug delivery through the skin's stratum corneum. This review covers traditional and novel enhancers, highlighting the benefits of combining enhancers for efficient skin penetration.
Area of Science:
- Dermatology
- Pharmaceutics
- Drug Delivery
Background:
- The stratum corneum presents a significant barrier to efficient transdermal drug delivery.
- Chemical penetration enhancers are widely used to overcome this barrier.
- Numerous enhancers with diverse properties and structures exist.
Purpose of the Study:
- To review traditional chemical penetration enhancers and their properties.
- To discuss the advantages of combining different chemical enhancers.
- To highlight novel compounds showing promise for enhanced skin delivery.
Main Methods:
- Literature review of traditional and novel chemical penetration enhancers.
- Analysis of enhancer properties and mechanisms of action.
- Evaluation of combination strategies for enhanced skin penetration.
Main Results:
- Chemical enhancers are a well-established strategy for improving skin penetration.
- Combining enhancers can offer synergistic effects for increased drug delivery.
- Novel compounds demonstrate potential for advanced transdermal drug delivery.
Conclusions:
- Chemical penetration enhancers are vital for effective transdermal drug delivery.
- Combinatorial approaches and novel enhancers offer promising avenues for future research.
- Optimizing enhancer use can significantly improve drug delivery efficiency into and across the skin.