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Updated: Apr 1, 2026

Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
Hypoglycemia associated with non-islet cell tumors
Unlabelled:
Tumor hypoglycemia is rare but life-threatening medical condition which may be associated with insulinoma and non-islet cell tumors (mainly of mesenchymal origin). The pathogenesis is connected with abnormal processing of insulin-like growth factor-2 (IGF-2) precursor and production of pathognomic "big" IGF-2 - incompletely processed posttranslational precursor of IGF-2, which is responsible for hypoglycemia. Other typical laboratory features include low level of fasting glucose and C-peptide, low IGF-1 and increased IGF-2 : IGF-1 ratio. Although paraneoplastic hypoglycemia is often present in patients with already diagnosed malignancy, it is necessary to consider this possibility in patients having unclear and inexplicable hypoglycemia. The adequate treatment can significantly reduce the symptoms and improve the quality of life.
Keywords:
tumor hypoglycemia, non-islet cell tumor, insulin-like growth factor.
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