Jove
Visualize
Contact Us

Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

866
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
866
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

704
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
704
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

2.1K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
2.1K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

1.4K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.4K
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

1.5K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Innovative vaccine approaches-a Keystone Symposia report.

Annals of the New York Academy of Sciences·2022
Same author

A BAFF/APRIL axis regulates obesogenic diet-driven weight gain.

Nature communications·2021
Same author

Microbiota maintain colonic homeostasis by activating TLR2/MyD88/PI3K signaling in IL-10-producing regulatory B cells.

The Journal of clinical investigation·2019
Same author

CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.

The Journal of clinical investigation·2018
Same author

Erratum: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Nature medicine·2017
Same author

CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.

The Journal of clinical investigation·2017
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 1, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

2.4K

Transformative tools for tackling tuberculosis.

Jennifer L Gardiner1, Christopher L Karp1

  • 1Discovery and Translational Sciences, Global Health, Bill & Melinda Gates Foundation, Seattle, WA 98102 jennifer.gardiner@gatesfoundation.org chris.karp@gatesfoundation.org.

The Journal of Experimental Medicine
|October 14, 2015
PubMed
Summary
This summary is machine-generated.

Effective tuberculosis control requires better diagnostic tools for Mycobacterium tuberculosis. New methods are needed to detect infection, predict treatment response, and understand host-pathogen interactions for improved global health strategies.

More Related Videos

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

9.2K
The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

19.8K

Related Experiment Videos

Last Updated: Apr 1, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

2.4K
System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

9.2K
The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

19.8K

Area of Science:

  • Microbiology and Immunology
  • Infectious Disease Diagnostics
  • Tuberculosis Research

Background:

  • Global tuberculosis (TB) control is hindered by limitations in current diagnostic and research tools.
  • Existing methods struggle to accurately detect Mycobacterium tuberculosis (M.tb) and understand its complex interaction with the human host.
  • There is a critical need for advanced tools to address TB detection and management challenges.

Purpose of the Study:

  • To review the current landscape of tools for tuberculosis detection and host-pathogen interaction studies.
  • To identify key deficiencies in existing methodologies for TB control.
  • To highlight the necessity for novel experimental paradigms to accelerate the development of improved diagnostic and research tools.

Main Methods:

  • Review of current scientific literature and diagnostic technologies for Mycobacterium tuberculosis.
  • Analysis of existing challenges in TB diagnostics, including sensitivity, specificity, and non-sputum based approaches.
  • Discussion of the need for biomarkers predicting therapy response, disease risk, and infection markers independent of host response.

Main Results:

  • Current tools for detecting Mycobacterium tuberculosis and understanding host-pathogen dynamics are insufficient for effective TB control.
  • Significant gaps exist in the availability of sensitive, specific, non-sputum diagnostics and predictive biomarkers.
  • Tools capable of quantifying total body M. tuberculosis burden are identified as potentially transformative.

Conclusions:

  • Advancements in TB control necessitate the development of highly sensitive and specific diagnostic tools.
  • New biomarkers and methods to quantify M. tuberculosis burden are crucial for improving therapeutic strategies and understanding disease progression.
  • A paradigm shift in experimental approaches is required to facilitate the discovery, validation, and implementation of next-generation TB tools.