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Age-dependent decrease in desflurane concentration for maintaining bispectral index below 50.

S Kanazawa1, Y Oda1, C Maeda1

  • 1Department of Anesthesiology, Osaka City General Hospital, Osaka, Japan.

Acta Anaesthesiologica Scandinavica
|October 14, 2015
PubMed
Summary
This summary is machine-generated.

The minimum alveolar concentration (MAC) of desflurane needed to keep the Bispectral Index (BIS) below 50 decreases with age. Elderly patients require significantly lower desflurane concentrations for adequate anesthesia depth.

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Area of Science:

  • Anesthesiology
  • Geriatric Medicine
  • Pharmacology

Background:

  • Investigated the relationship between patient age and the anesthetic requirements of desflurane.
  • Examined the hypothesis that the minimum alveolar concentration (MAC) of desflurane for maintaining Bispectral Index (BIS) below 50 (MACBIS 50) decreases with advancing age.

Purpose of the Study:

  • To determine if the minimum alveolar concentration of desflurane required to maintain a Bispectral Index (BIS) below 50 (MACBIS 50) is influenced by age.
  • To quantify the age-related differences in desflurane MAC requirements for adequate anesthesia depth.

Main Methods:

  • A study involving 60 patients aged 20-80 years, divided into young, middle-aged, and elderly groups (n=20 each).
  • General anesthesia was induced with propofol and rocuronium after remifentanil infusion.
  • MACBIS 50 was estimated using the up-down method, assessing BIS at stable end-tidal desflurane concentrations.

Main Results:

  • MACBIS 50 for desflurane was 4.25% in young, 3.58% in middle-aged, and 2.75% in elderly patients.
  • Elderly patients required significantly lower end-tidal desflurane concentrations compared to middle-aged and young patients (P=0.012).
  • Young patients required significantly higher end-tidal desflurane concentrations compared to middle-aged patients (P=0.011).

Conclusions:

  • Advancing age significantly reduces the end-tidal desflurane concentration needed to maintain BIS below 50.
  • The Bispectral Index (BIS) effectively reflects age-associated decreases in desflurane requirements for adequate anesthesia depth.