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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
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Opioid Induced Hyperalgesia
Peter Yi1, Peter Pryzbylkowski1
1Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA.
Pain Medicine (Malden, Mass.)
|October 14, 2015
Summary
Opioid induced hyperalgesia (OIH) is a growing concern with increased opioid use for chronic pain. Further research is needed to understand and manage this complex condition.
Area of Science:
- Pain Management
- Pharmacology
- Neuroscience
Background:
- Opioid-induced hyperalgesia (OIH) is a paradoxical increase in pain sensitivity caused by opioid administration.
- The prevalence of OIH is significant, particularly with long-term opioid therapy for chronic nonmalignant pain.
Purpose of the Study:
- To review the current understanding of opioid-induced hyperalgesia (OIH).
- To investigate available data and clinical recommendations for managing OIH.
Main Methods:
- A comprehensive literature search was conducted on opioid-induced hyperalgesia.
- Relevant studies and reviews were included for analysis.
Main Results:
- The review discusses the pathophysiology, diagnosis, and clinical management of OIH.
- Updated data and literature references are presented.
Conclusions:
- OIH is an increasingly relevant issue due to widespread opioid prescribing.
- Further research is essential to elucidate OIH mechanisms and improve patient care.
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