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1,3-β-D-glucan in cryptococcal meningitis

Joshua Rhein1, David R Boulware2, Nathan C Bahr2

  • 1Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA; Infectious Disease Institute, Makerere University, Kampala, Uganda.

The Lancet. Infectious Diseases
|October 14, 2015
PubMed
Summary

No abstract available in PubMed .

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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