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Updated: Aug 5, 2026

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
Published on: October 10, 2020
The glutathione S-transferases: an update
1Department of Medicine, Veterans Administration Medical Center, San Francisco, California 94121.
Researchers are exploring the diverse roles of glutathione transferases (GST) and their isozymes in cellular functions and regulation. Future studies aim to uncover new functions for these versatile proteins.
Area of Science:
- Biochemistry
- Molecular Biology
- Cellular Biology
Background:
- Over 15 years, multiple forms of glutathione transferases (GST) have been identified across various species and organs.
- Initial research focused on identification and characterization of GST isozymes.
Purpose of the Study:
- To define the specific roles of numerous GST isozymes in cellular functions.
- To establish the relationship between the structure and function of different GST isozymes.
- To determine the regulatory mechanisms of GST expression in various tissues.
Main Methods:
- Characterization of GST isozymes.
- Functional analysis of GST isozymes.
- Investigation of GST gene expression regulation.
Main Results:
- Identification and characterization of multiple GST forms.
- Ongoing research to elucidate isozyme-specific functions.
- Studies investigating GST structure-function relationships are in progress.
Conclusions:
- Glutathione transferases (GST) are a family of multifunctional proteins with significant roles in cell biology.
- Further research is expected to reveal novel functions and regulatory pathways for GST.
- The study of GST isozymes will continue to be an active area of investigation for many years.
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