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Localization of Radiolabeled Somatostatin Analogs in the Spleen
Marleen Melis1, Daniel Kaemmerer, Jan de Swart
1From the *Department of Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands; †Department of General and Visceral Surgery, and ‡Theranostics Center for Molecular Radiotherapy and Molecular Imaging, Zentralklinik Bad Berka, Bad Berka; §Institute of Pharmacology and Toxicology, Jena University Hospital, Jena; ∥Laboratory of Pathology and Cytology, Zentralklinik Bad Berka, Bad Berka, Germany; and ¶Department of Radiology, Erasmus MC, Rotterdam, the Netherlands.
Abstract:
Radiolabeled somatostatin (SST) analogs, used to visualize and treat SST receptor (SSTR)-expressing neuroendocrine tumors, also accumulate in the spleen. There is a high interpatient variation and no significant radiation-induced splenic toxicity; however, an absorbed dose-related reduction in spleen size was detected. However, the exact localization of radioactivity and the role of SST receptors in splenic retention are unknown. Therefore, we performed ex vivo micro-SPECT of the isolated spleen from a patient with a pancreatic neoplasm after 1 GBq (27 mCi) Lu-DOTATATE administration, followed by autoradiography and immunohistochemistry. Ex vivo autoradiography demonstrated convincingly that most radioactivity accumulated in red pulp.
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