Mesenteric Panniculitis Demonstrated on 18F-FDG PET/CT
Domenico Albano1, Giovanni Bosio, Francesco Bertagna
1From the *Nuclear Medicine, Spedali Civili Brescia, and †Nuclear Medicine, University of Brescia, Brescia, Italy.
Abstract:
Mesenteric panniculitis is an underdiagnosed inflammatory condition of unknown etiology that involves the mesenteric adipose tissue. Clinical symptoms are not specific (fever, abdominal pain, or nausea), so diagnosis is not simple. We report a case of 48-year-old man with abdominal pain and fever not responsive to antipyretics and antibiotics for 2 months, who underwent an F-FDG PET/CT after a nondiagnostic CT scan. PET/CT has proven to be a useful method for the diagnosis of mesenteric panniculitis in this patient, showing a uniformly high uptake of FDG in the mesenteric adipose tissue of the mesocolon, mesoappendix, mesosigmoid, and mesorectum.
Insights
Mesenteric panniculitis, an inflammatory condition, can be challenging to diagnose due to non-specific symptoms. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) aids in diagnosing this condition by showing characteristic metabolic activity.
Area of Science:
- Gastroenterology
- Radiology
- Nuclear Medicine
Background:
- Mesenteric panniculitis is an inflammatory condition affecting mesenteric adipose tissue.
- Its etiology is unknown, and clinical symptoms like abdominal pain and fever are non-specific, complicating diagnosis.
Observation:
- A 48-year-old man presented with persistent abdominal pain and fever unresponsive to initial treatments.
- A computed tomography (CT) scan was inconclusive.
- An F-FDG PET/CT scan was performed for further investigation.
Findings:
- The F-FDG PET/CT scan revealed uniformly high uptake of F-FDG in the mesenteric adipose tissue.
- This uptake was observed across the mesocolon, mesoappendix, mesosigmoid, and mesorectum.
Implications:
- F-FDG PET/CT can be a valuable diagnostic tool for mesenteric panniculitis.
- This imaging modality can help identify characteristic metabolic patterns in affected mesenteric tissues.
- Early and accurate diagnosis can potentially lead to better patient management.
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