Related Experiment Video
Updated: Apr 1, 2026

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
Published on: August 21, 2020
[ROLE OF microRNA IN SKIN DEVELOPMENT AND WOUND HEALING]
Objective:
To review the role of microRNA (miRNA) in skin development and wound healing.
Methods:
The recent literature about miRNA in skin development and wound healing was reviewed and analyzed.
Results:
miRNA extensively involved in the development of the skin, including epidermal cell proliferation, differentiation, aging and hair follicle development; miR-203 known as the "skin-specific miRNA" can directly inhibit the expression of p63 and promote the differentiation of the epidermis. Meanwhile, miRNA also involved in various stages of skin regeneration and wound healing. Abnormal expression of miRNA is closely related with abnormal wound healing.
Conclusion:
miRNA play an important role in maintaining normal skin physiology and skin regeneration. To explore their roles in the healing of skin wounds and their regulatory mechanism can provide a new target for the treatment, which has a potential value and broad prospects.
Related Concept Videos
MicroRNAs
MicroRNAs
MicroRNAs
Clinical Applications of Epidermal Stem Cells
Renewal of Skin Epidermal Stem Cells
The Skin Microbiota

