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A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

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Published on: July 28, 2023

Gut microbiota-bone axis.

Christopher R Villa¹, Wendy E Ward^1,2, Elena M Comelli¹

¹a Department of Nutritional Sciences , University of Toronto , Toronto , Ontario , Canada.

Critical Reviews in Food Science and Nutrition

|October 15, 2015

Summary

This summary is machine-generated.

The gut microbiota influences bone health, with probiotics like Lactobacillus showing promise in preclinical studies for improving bone density and strength. Further research is needed to optimize their use, considering age and sex.

Keywords:

Development aging bone mineral density bone structure probiotics

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Area of Science:

Microbiology
Bone Biology
Gastroenterology

Background:

The gut microbiota (GM) plays a crucial role in maintaining body homeostasis, affecting both intestinal and extra-intestinal sites.
The GM-bone axis describes the influence of gut microbes and their metabolites on skeletal health.

Purpose of the Study:

To review the current understanding of the gut microbiota's impact on bone health.
To identify key microbial players and potential therapeutic interventions for the GM-bone axis.

Main Methods:

Literature review of preclinical studies investigating the relationship between gut microbiota and bone parameters.
Analysis of findings related to microbial modulation of bone mineral density and strength.

Main Results:

Preclinical evidence suggests a positive correlation between gut microbes and improved bone mineral density and strength.
Administration of probiotics, particularly Lactobacillus, has shown enhanced bone mineralization and strength in animal models.
Early life and sex-specific differences appear to influence the efficacy of probiotic interventions.

Conclusions:

The gut microbiota significantly impacts bone health, establishing the GM-bone axis.
Lactobacillus species show potential as probiotics for bone health interventions.
Further research is required to elucidate mechanisms, optimize probiotic dosage, timing, and duration, and understand sex-specific effects.