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Updated: Apr 1, 2026
Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
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The copper binding properties of metformin--QCM-D, XPS and nanobead agglomeration
Xueling Quan1, Rokon Uddin1, Arto Heiskanen1
1Department of Micro- and Nanotechnology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. Anja.Boisen@nanotech.dtu.dk Xueling.Quan@nanotech.dtu.dk.
Abstract:
Study of the copper binding properties of metformin is important for revealing its mechanism of action as a first-line type-2 diabetes drug. A quantitative investigation of interactions between metformin and L-cysteine-copper complexes was performed. The results suggest that metformin could interact with biological copper, which plays a key role in mitochondrial function.
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