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Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization

Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization

Published on: June 19, 2015

Fluorescence imaging enabled poly(lactide-co-glycolide).

Jianqing Hu¹, Jinshan Guo², Zhiwei Xie²

¹School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China; Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of The Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.

Acta Biomaterialia

|October 15, 2015

Summary

This summary is machine-generated.

Researchers developed biodegradable, fluorescent poly(lactide-co-glycolide) (BPLP-co-PLGA) copolymers. These materials offer tunable, stable photoluminescence for imaging and theranostics without toxic dyes, expanding PLGA applications.

Keywords:

Biodegradable Bioimaging Drug delivery PLGA Photoluminescence Tissue engineering

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Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Published on: September 8, 2016

Area of Science:

Biomaterials Science
Polymer Chemistry
Fluorescence Imaging

Background:

Biodegradable polymers like poly(lactide-co-glycolide) (PLGA) are widely used but lack intrinsic fluorescence.
Conventional fluorescent labeling often involves cytotoxic quantum dots or photobleaching organic dyes.
There is a need for intrinsically fluorescent, biocompatible materials for advanced biomedical applications.

Purpose of the Study:

To develop novel biodegradable and fluorescent poly(lactide-co-glycolide) (PLGA) copolymers.
To evaluate the photoluminescence properties, degradation behavior, and biocompatibility of these new copolymers.
To demonstrate the potential applications in imaging, tissue engineering, and drug delivery.

Main Methods:

Synthesis of biodegradable photoluminescent poly(lactide-co-glycolide) (BPLP-co-PLGA) copolymers.
Photoluminescence characterization of solutions, films, and nanoparticles.
Degradation studies by adjusting monomer ratios (L-lactide/glycolide and (LA+GA)/BPLP).
In vitro cytotoxicity and in vivo foreign body response assessments.
Fabrication of porous scaffolds and nanoparticles for application demonstrations.

Main Results:

BPLP-co-PLGA exhibits strong, tunable, and stable photoluminescence.
The copolymers degrade fully within 8-16 weeks, with fluorescence decay monitoring degradation.
BPLP-co-PLGA shows biocompatibility comparable to conventional PLGA.
Demonstrated theranostic potential using nanoparticles for cellular imaging and drug delivery.
Fabricated scaffolds showed non-invasive imaging-based degradation monitoring.

Conclusions:

Developed intrinsically fluorescent PLGA copolymers (BPLP-co-PLGA) without cytotoxic or photobleaching agents.
These materials offer a promising alternative for applications requiring fluorescence.
Potential impact in tissue engineering, molecular imaging, labeling, and drug delivery systems.