Emerging Technologies for Next-Generation Point-of-Care Testing.
Sandeep Kumar Vashist1, Peter B Luppa1, Leslie Y Yeo2
1Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, D-81675 Munich, Germany.
Trends in Biotechnology
|October 15, 2015
Summary
Innovations in cellphone-based technologies and paper-based assays are driving advances in point-of-care testing (POCT). While these technologies offer cost-effective healthcare, challenges remain for widespread clinical implementation.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Point-of-Care Diagnostics
Background:
- Point-of-care testing (POCT) devices have seen significant advancements.
- Innovations include cellphone (CP)-based technologies, paper-based assays (PBAs), and lab-on-a-chip (LOC) platforms.
Purpose of the Study:
- To review recent innovations in POCT.
- To highlight the role of emerging technologies in mobile healthcare and personalized medicine.
Main Methods:
- Review of current literature and commercial platforms in POCT.
- Analysis of assay formats, reagent stabilization strategies, and implementation challenges.
Main Results:
- Commercial cellphone platforms offer cost-effective mobile healthcare solutions.
- Low-cost PBAs and LOC assays enable robust, automated, and simplified POCT.
- Strategies for ambient temperature reagent stabilization have been developed.
Conclusions:
- Emerging POCT technologies promise accessible and personalized medicine.
- Challenges in commercialization and widespread clinical adoption persist.
- Further development is needed to overcome existing hurdles for successful implementation.
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