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Cytotoxicity and sustained release of modified divinylsulfone from silk based 3D construct
Tuli Dey1,2, Banani Kundu1,3, Debanjana Deb4
1Department of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, 721302, India.
Journal of Materials Science. Materials in Medicine
|October 15, 2015
Summary
Modified divinylsulfones (mDVS2) show promise as a novel therapeutic agent. This research details their synthesis and demonstrates their potent cytotoxic effects on breast cancer cells, paving the way for new cancer treatments.
Area of Science:
- Biochemistry
- Materials Science
- Oncology
Background:
- Monovinylsulfones are well-researched for biological activity.
- Modified divinylsulfones (mDVS2) have been underutilized due to synthetic challenges.
Purpose of the Study:
- To explore the therapeutic potential of a unique modified divinylsulfone derivative (mDVS2).
- To investigate the cytotoxic effects of mDVS2 on breast cancer cells.
- To develop a sustained-release system for mDVS2 using 3D scaffolds.
Main Methods:
- Developed an accessible synthesis route for mDVS2.
- Assessed mDVS2's cytotoxicity against invasive and non-invasive breast cancer cells.
- Fabricated mDVS2-embedded silk-based 3D scaffolds for sustained release.
Main Results:
- mDVS2 demonstrated time- and concentration-dependent necrosis induction in breast cancer cells.
- mDVS2-loaded scaffolds achieved 100% cell death within 7 days, indicating sustained activity.
- The synthesis route provides mDVS2 in reasonably large quantities.
Conclusions:
- Modified divinylsulfones (mDVS2) possess significant cytotoxic properties.
- mDVS2 is a promising candidate for breast cancer therapy.
- Underutilized mDVSs warrant further investigation as potential therapeutic agents.
