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Whole-Body Diffusion Tensor Imaging: A Feasibility Study.

David Kenkel1, Jochen von Spiczak, Moritz C Wurnig

  • 1From the *Department of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland; †Section of Experimental Radiology, University Hospital Tubingen, Tubingen, Germany; and ‡Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland.

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|October 15, 2015
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Summary
This summary is machine-generated.

Whole-body diffusion tensor imaging (DTI) is feasible for research, particularly for studying systemic muscle diseases. Further improvements in signal-to-noise ratio and resolution are needed for clinical use.

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Area of Science:

  • Biomedical Imaging
  • Radiology
  • Neuroimaging

Background:

  • Diffusion Tensor Imaging (DTI) is a powerful MRI technique for visualizing tissue microstructure.
  • Whole-body DTI has the potential to assess systemic conditions affecting multiple organs.

Purpose of the Study:

  • To evaluate the feasibility of whole-body DTI for research applications.
  • To explore its utility in investigating systemic muscle diseases.

Main Methods:

  • Whole-body MRI at 3T was performed on 12 healthy volunteers using echo planar imaging.
  • DTI parameters (mean diffusivity, fractional anisotropy, eigenvalues) were calculated using MATLAB.
  • Region-of-interest analysis was conducted on skeletal muscle, brain, kidneys, and liver.

Main Results:

  • Whole-body DTI acquisition took approximately 79 minutes.
  • Parametric maps clearly depicted various organs.
  • Exemplary DTI values were obtained for skeletal muscle.

Conclusions:

  • Whole-body DTI is technically feasible for research.
  • Enhancements in signal-to-noise ratio and spatial resolution are necessary.
  • Potential clinical applications include assessing systemic myopathies.