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Quantitative analysis of iris parameters in keratoconus patients using optical coherence tomography
Gustavo Bonfadini1, Karun Arora2, Lucas M Vianna1
1Cornea and Anterior Segment Service, The Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD, US.
Arquivos Brasileiros De Oftalmologia
|October 15, 2015
Summary
Iris thickness is reduced in keratoconus eyes compared to healthy eyes. This finding suggests iris thickness measurements may aid in keratoconus screening.
Area of Science:
- Ophthalmology
- Corneal Diseases
Background:
- Keratoconus is a progressive thinning disorder of the cornea.
- Early detection of keratoconus is crucial for effective management and preventing vision loss.
Purpose of the Study:
- To determine the association between quantitative iris parameters and the presence of keratoconus.
- To evaluate the diagnostic potential of iris measurements in identifying keratoconus.
Main Methods:
- A cross-sectional observational study comparing 15 keratoconus eyes with 26 normal control eyes.
- Iris parameters (area, thickness, pupil diameter) measured using anterior segment optical coherence tomography (AS-OCT) under varying light conditions.
- Receiver operating characteristic (ROC) curve analysis to determine optimal iris thickness cutoffs for keratoconus discrimination.
Main Results:
- Keratoconus eyes exhibited significantly lower iris thickness and area compared to normal eyes.
- Iris thickness at the pupillary margin was the most effective parameter for differentiating keratoconus from normal eyes.
- An iris thickness cutoff of 0.4125 mm achieved 80.0% sensitivity and 84.6% specificity (Area Under ROC Curve [AROC] = 0.8256).
Conclusions:
- Reduced iris thickness is a characteristic finding in keratoconus eyes.
- Iris thickness measurements show promise as an adjunct tool for keratoconus screening.
