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Three-dimensional bioprinting in tissue engineering and regenerative medicine
Guifang Gao1,2,3, Xiaofeng Cui4,5
1School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, 122 Luoshi Road, Wuhan, Hubei, China.
Biotechnology Letters
|October 16, 2015
Summary
Thermal inkjet bioprinting enables precise, high-throughput engineering of tissues like vasculature, muscle, cartilage, and bone. This technology holds significant promise for regenerative medicine and drug delivery applications.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Tissue Engineering
Background:
- Advances in stem cell research, biomaterials, and 3D biofabrication enable engineered tissues and organs.
- Inkjet-based bioprinting offers high throughput, digital control, and single-cell manipulation for tissue creation.
Purpose of the Study:
- To review current advancements in organ and tissue bioprinting using thermal inkjet printing technology.
- To highlight the potential of bioprinting in regenerative medicine, drug delivery, and complex tissue construction.
Main Methods:
- Review of current literature on thermal inkjet bioprinting techniques.
- Focus on applications in engineering vasculature, muscle, cartilage, and bone tissues.
- Discussion of layer-by-layer assembly using converted medical images for 3D tissue printing.
Main Results:
- Thermal inkjet bioprinting is effective for creating vascularized tissues, crucial for thick and complex constructs.
- The process allows for precise cell placement, enabling potential applications in gene and drug delivery.
- 3D tissues with intricate structures can be fabricated using digital imaging and layer-by-layer assembly.
Conclusions:
- Thermal inkjet bioprinting is a highly promising technology for tissue engineering and regenerative medicine.
- Future directions include integrating diverse printing mechanisms for multi-tissue constructs and advancing stem cell biology understanding.
