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Related Experiment Video

Updated: Mar 31, 2026

Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts
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Cumulative live birth rate: time for a consensus?

Abha Maheshwari1, David McLernon2, Siladitya Bhattacharya2

  • 1Aberdeen Fertility Centre, NHS Grampian, Foresterhill, Aberdeen, UK abha.maheshwari@abdn.ac.uk.

Human Reproduction (Oxford, England)
|October 16, 2015
PubMed
Summary

To accurately measure in vitro fertilization (IVF) success, cumulative live birth rates should include both fresh and frozen embryo transfers. An international consensus is needed to standardize the calculation and reporting of this vital IVF metric.

Keywords:
IVF, ICSIcumulative live birth rateembryo transferfresh embryo transferfrozen embryo transferlife tablespregnancy

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Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization
  • Biostatistics

Background:

  • Traditional in vitro fertilization (IVF) success reporting focuses on live birth rates per fresh cycle or embryo transfer.
  • The increasing prevalence of embryo cryopreservation necessitates a more comprehensive approach to measuring IVF treatment outcomes.
  • Current reporting methods do not fully capture the complete success of an IVF treatment cycle when including frozen embryo transfers.

Purpose of the Study:

  • To highlight the importance of including frozen embryo transfer outcomes in IVF success rate reporting.
  • To advocate for the adoption of cumulative live birth rate as the standard metric for IVF success.
  • To emphasize the need for an international consensus on the calculation, reporting, and interpretation of cumulative live birth rates in IVF.

Main Methods:

  • Review of current practices in reporting IVF success rates.
  • Discussion of the limitations of traditional reporting metrics.
  • Analysis of the components required for calculating cumulative live birth rates, including fresh and frozen embryo transfers.

Main Results:

  • Existing methods for reporting IVF success are insufficient due to the widespread use of embryo freezing.
  • Cumulative live birth rate is widely considered the most appropriate measure for overall IVF treatment success.
  • Inconsistent methodologies exist for calculating cumulative live birth rates, impacting interpretation.

Conclusions:

  • Reporting IVF success solely based on fresh cycles is no longer adequate.
  • A standardized international approach to calculating and reporting cumulative live birth rates is essential for accurate IVF outcome assessment.
  • Consideration of factors like the time for all frozen embryos to be utilized is crucial for a complete understanding of treatment success.