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Updated: Mar 31, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
Published on: June 9, 2017
Structural Studies of G Protein-Coupled Receptors
Dandan Zhang1, Qiang Zhao1, Beili Wu1
1CAS Key Laboratory of Receptor Research, Shanghai Institute of Mate-ria Medica, Chinese Academy of Sciences, Pudong, Shanghai 201203, China.
Abstract:
G protein-coupled receptors (GPCRs) constitute the largest and the most physiologically important membrane protein family that recognizes a variety of environmental stimuli, and are drug targets in the treatment of numerous diseases. Recent progress on GPCR structural studies shed light on molecular mechanisms of GPCR ligand recognition, activation and allosteric modulation, as well as structural basis of GPCR dimerization. In this review, we will discuss the structural features of GPCRs and structural insights of different aspects of GPCR biological functions.
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