Related Experiment Videos
MesobanK UK: an international mesothelioma bioresource
Robert C Rintoul1, Doris M Rassl2, Jacki Gittins3
1Department of Thoracic Oncology, Papworth Hospital, Cambridge, UK.
Abstract:
Malignant pleural mesothelioma causes the greatest societal burden of all the asbestos-related diseases. Progress in better understanding tumour biology will be facilitated by the availability of quality-assured annotated tissue. MesobanK has been created to establish a bioresource of pleural mesothelioma tissue linked to detailed anonymised clinical data. When complete, the bioresource will comprise a 750-patient tissue microarray and prospectively collected tissue, blood and pleural fluid from 300 patients with mesothelioma. Twenty-six new cell lines have also been developed. MesobanK meets all appropriate ethical and regulatory procedures and has recently opened to requests for tissue and data.
Insights
MesobanK provides a valuable bioresource of malignant pleural mesothelioma tissue and clinical data. This resource aims to advance the understanding of asbestos-related diseases and improve patient outcomes.
Area of Science:
- Oncology
- Pathology
- Biobanking
Background:
- Malignant pleural mesothelioma is a significant asbestos-related disease with a substantial societal burden.
- Understanding tumor biology is crucial for advancing treatment strategies.
- Quality-assured, annotated tissue samples are essential for research.
Purpose of the Study:
- To establish MesobanK, a comprehensive bioresource for pleural mesothelioma research.
- To link annotated tissue samples with detailed anonymized clinical data.
- To facilitate research into the biology and treatment of malignant pleural mesothelioma.
Main Methods:
- Creation of a 750-patient tissue microarray.
- Prospective collection of tissue, blood, and pleural fluid from 300 mesothelioma patients.
- Development of 26 new mesothelioma cell lines.
- Adherence to ethical and regulatory standards for biobanking.
Main Results:
- MesobanK has been established as a bioresource for pleural mesothelioma.
- The bioresource includes a tissue microarray, prospectively collected patient samples, and new cell lines.
- MesobanK is now open for tissue and data requests.
Conclusions:
- MesobanK provides a critical resource for advancing malignant pleural mesothelioma research.
- The integrated tissue and clinical data will support deeper insights into mesothelioma biology.
- This bioresource is expected to contribute to improved understanding and management of asbestos-related diseases.