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Published on: March 28, 2025
Diagnosis and Management of Thoracic Aortic Disease
David M Dudzinski1, Eric M Isselbacher2
1Thoracic Aortic Center, Massachusetts General Hospital, Yawkey 5, Boston, MA, 02114, USA. ddudzinski@partners.org.
Insights
Thoracic aortic aneurysms are often silent and found incidentally. Management includes medication and imaging, with repair based on rupture risk, while acute aortic syndromes require prompt treatment, often surgically.
Area of Science:
- Cardiovascular Medicine
- Vascular Surgery
- Diagnostic Imaging
Background:
- Thoracic aortic aneurysms (TAAs) are frequently asymptomatic, detected incidentally during imaging for other conditions.
- Management of small TAAs involves antihypertensive therapy and surveillance via echocardiography, CTA, or MRA.
- Repair decisions are based on rupture risk, with lower thresholds for genetic aortopathies.
Purpose of the Study:
- To outline the diagnostic and management strategies for thoracic aortic aneurysms and acute aortic syndromes.
- To differentiate the clinical presentation and treatment of aneurysms versus acute aortic syndromes.
- To emphasize the importance of follow-up care after treatment.
Main Methods:
- Review of current clinical practices for TAA and acute aortic syndrome management.
- Discussion of imaging modalities (echocardiography, CTA, MRA) for surveillance.
- Analysis of surgical and endovascular treatment approaches based on aneurysm location and etiology.
Main Results:
- TAAs are typically asymptomatic; management is conservative for small aneurysms and surgical for larger ones or those at high risk of rupture.
- Acute aortic syndromes present with symptoms and require timely intervention, with surgery for ascending aorta and endovascular repair for descending aorta.
- Successful treatment of acute aortic syndromes leads to favorable prognosis with ongoing medical management and surveillance.
Conclusions:
- Effective management of thoracic aortic pathology requires accurate diagnosis, risk stratification, and tailored treatment strategies.
- Prompt intervention for acute aortic syndromes is critical for favorable outcomes.
- Long-term follow-up, including medical management and surveillance imaging, is essential after treatment for both aneurysms and acute aortic syndromes.
Abstract:
Thoracic aortic aneurysms are typically asymptomatic and discovered incidentally on an imaging study ordered for other indications. Small aneurysms are managed with antihypertensive therapy and surveillance imaging, using either echocardiography, computed tomographic angiography (CTA), or magnetic resonance angiography (MRA). Aneurysms are repaired when the risk of rupture or dissection exceeds the risk of repair; size thresholds for repair are determined by the underlying etiology of the aneurysm, with lower thresholds for those with genetic aortopathies. In contrast to the silent and asymptomatic nature of aneurysms, acute aortic syndromes-which include aortic dissection, intramural hematoma, and penetrating atherosclerotic ulcer-are usually associated with recognizable symptoms and signs. Acute aortic syndromes involving the ascending aorta are treated with emergent surgery, whereas those involving the descending aorta are now often treated with endovascular stent-grafting techniques. After acute aortic syndromes have been successfully treated, prognosis is favorable with close follow-up that includes optimal medical management and regular surveillance imaging.
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