Related Experiment Video
Updated: Mar 31, 2026
14:18
Fluorescence-based Measurement of Store-operated Calcium Entry in Live Cells: from Cultured Cancer Cell to Skeletal Muscle Fiber
Published on: February 13, 2012
21.9K
Store-operated calcium entry and diabetic complications
1Department of Integrative Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth 76107, TX, USA.
Experimental Biology and Medicine (Maywood, N.J.)
|October 16, 2015
Summary
Store-operated calcium entry (SOCE) is crucial for cell function. Altered SOCE is linked to diabetic complications like nephropathy and vasculopathy, suggesting it as a therapeutic target.
Area of Science:
- Biochemistry
- Cell Biology
- Physiology
Background:
- Store-operated calcium entry (SOCE) is a fundamental cellular mechanism.
- SOCE regulates intracellular calcium levels following receptor activation.
- Dysregulation of SOCE is increasingly implicated in various pathologies.
Purpose of the Study:
- To review the role of SOCE in diabetic complications.
- To summarize recent findings on abnormal SOCE in diabetes.
- To discuss mechanisms underlying diabetes-associated SOCE alterations.
Main Methods:
- Literature review of studies on SOCE and diabetes.
- Synthesis of evidence linking SOCE to diabetic nephropathy and vasculopathy.
- Analysis of molecular mechanisms affecting SOCE in diabetes.
Main Results:
- Accumulating evidence links altered SOCE to diabetic complications.
- Abnormal SOCE contributes to the development of diabetic nephropathy.
- Dysregulated SOCE is involved in diabetic vasculopathy progression.
Conclusions:
- Altered SOCE is a significant factor in diabetes-associated diseases.
- Understanding SOCE mechanisms in diabetes is critical.
- The SOCE pathway presents a potential therapeutic target for diabetic complications.
More Related Videos
Related Concept Videos
01:18Antihypertensive Drugs: Action of Calcium Channel Blockers
2.2K
Calcium ions are essential to contract smooth muscle cells in blood vessels. They enter these cells through voltage-dependent calcium channels, specifically L-type calcium channels in the cell membrane. These L-type calcium channels are integral to the excitation-contraction coupling process in smooth muscle. When a stimulus is received by smooth muscle cells, their membrane depolarizes. This alteration in membrane potential instigates the opening of L-type calcium channels. As a result,...
2.2K
01:27Feedback Regulation of Calcium Concentration
4.2K
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
4.2K
01:21Skeleton and Calcium Homeostasis
8.3K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
8.3K
01:30Ligand-Gated Ion Channel Receptor: Gating Mechanism
4.8K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.8K
01:16Calmodulin-dependent Signaling
7.0K
Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
7.0K
01:17Hormones and Bone Tissue
4.2K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
4.2K